EPSTEIN-BARR VIRUS EVADES RESTRICTIVE HOST CHROMATIN CLOSURE BY SUBVERTING B CELL ACTIVATION AND GERMINAL CENTER REGULATORY LOCI

Epstein-Barr virus evades restrictive host chromatin closure by subverting B cell activation and germinal center regulatory loci

Summary: Chromatin accessibility fundamentally governs gene expression and biological response programs that can be manipulated by pathogens.Here we capture dynamic chromatin landscapes of individual B cells during Epstein-Barr virus (EBV) infection.EBV+ cells that exhibit arrest via antiviral sensing and proliferation-linked DNA damage experience

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Detecting online grooming at its earliest stages: development and validation of the Online Grooming Risk Scale

Backgrounds: Among the problematic online behaviours, online grooming, that is, a manipulative process leading to sexual solicitation between an adult and a minor, is receiving increasing attention.However, most of the studies come from qualitative data, confirming that a formalized measurement tool is still missing.Moreover, online grooming measur

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Case report: Alternative approach for management of refractory volume overload in heart failure: usefulness of venous leg compression

BackgroundManagement of patients with refractory congestion, is one of the most important challenges in the field of heart COFFEE FILTER BASKET failure (HF).Diuretic therapy remains the most widely used therapy to achieve euvolemia.However, some patients experience fluid overload despite the use of high-dose diuretics and new strategies to overcome

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